RMIC — Resistance Mechanism Characterisation
The RMIC strip is BioMaxima's resistance-focused gradient diffusion MIC test strip for quantitative determination of minimum inhibitory concentrations for resistance mechanism confirmation. The panel is pre-configured for the key antimicrobial agents required to characterise ESBL, AmpC, carbapenemase-producing organisms (KPC, OXA-48, NDM, VIM, IMP), MRSA, VRE, and colistin resistance.
Like all BioMaxima MIC strips, RMIC uses the patented biomedical composite carrier technology developed with Arctic Paper Kostrzyn S.A. — ensuring precise, reproducible antibiotic diffusion across 15 two-fold dilution steps. Results are directly comparable with EUCAST broth microdilution reference MIC values and support accurate clinical breakpoint application for AMR reporting and infection control.
RMIC strips are placed on Mueller-Hinton agar inoculated with the test organism. After 16–20 hours incubation at 35 ± 1°C, the MIC is read directly where the bottom of the ellipse intersects the graduated scale. No serial dilution preparation is required.
Results are interpreted using the current annual EUCAST Clinical Breakpoint Tables or CLSI M100, classifying isolates as S, I, or R. For carbapenem-resistant organisms, apply the most current EUCAST guidance and local antimicrobial stewardship protocols.
Why BioMaxima RMIC Strips
Developed through university research partnerships and a patented composite substrate — delivering consistent, reproducible gradient diffusion AST.
Biomedical Composite Carrier
RMIC strips use BioMaxima's patented biomedical composite carrier layer — delivering precise, consistent antibiotic diffusion across all 15 two-fold dilution steps with exceptional lot-to-lot reproducibility. Critical for resistance work where exact MIC thresholds determine clinical and public health decisions.
University-Validated Technology
The MIC test platform was developed through a five-year research programme (2017–2022) in collaboration with UMCS Lublin (Departments of Genetics and Microbiology, and Biochemistry) and the Medical University of Lublin — with two patent applications filed as a result.
EUCAST & CLSI Aligned
RMIC resistance agent gradients are validated against EUCAST and CLSI reference MIC distributions, ensuring interpretive agreement for key species/agent combinations used in Australian AMR surveillance and CPE reporting.
No Serial Dilution Required
Unlike broth microdilution, RMIC strips require no preparation of antibiotic dilution series. A single strip on an inoculated agar plate delivers the full 15-step gradient — reducing preparation time and minimising dilution error in resistance confirmation workflows.
Standard Laboratory Infrastructure
RMIC testing requires only standard microbiology laboratory equipment — incubator, agar plates, and a turbidity standard. Results in 16–20 hours using standard overnight incubation. Compatible with existing MIC strip applicators and workflows.
CPE Confirmation Workflow
Supports confirmatory carbapenem MIC determination following screening tests (e.g. CarbaNP, chromogenic agar), providing quantitative data required for clinical decision-making, public health reporting, and infection control protocols.
RMIC Resistance Panel — Key Agents & Mechanisms
The RMIC panel covers resistance-mechanism-specific agents across the priority resistance categories. Contact Advanced Biotech for the current full agent list and catalogue numbers.
Pack Sizes
RMIC strips are individually packaged, allowing selective ordering of resistance-relevant agents without committing to full susceptibility panels. Contact Advanced Biotech for pricing, catalogue numbers, and current availability.
Suitable for low-throughput testing, evaluation, or infrequent use of specific agents. Individually packaged strips maintain stability and reduce waste.
EnquireStandard pack size for routine clinical laboratory use. Cost-effective for regular AST workflows without requiring bulk storage of high-volume packs.
EnquireHigh-volume pack for reference laboratories, high-throughput clinical settings, or institutions requiring bulk supply of frequently tested agents.
EnquireTechnical Specifications
Key technical parameters for the RMIC Resistance MIC Test Strip.
| Parameter | Specification |
|---|---|
| Product name | BioMaxima Resistance MIC Strip (RMIC) |
| Platform | Gradient diffusion minimum inhibitory concentration (MIC) test |
| Target organisms | Aerobic and facultatively anaerobic bacteria (routine clinical isolates) |
| Antibiotic coverage | Resistance-mechanism-focused panel — ESBL, AmpC, CPE, MRSA, VRE, colistin resistance (contact Advanced Biotech for current full list) |
| Dilution range | 15 two-fold dilution steps — factory-calibrated continuous gradient |
| Test medium | Mueller-Hinton agar (standard formulation, EUCAST/CLSI specification) |
| Inoculum | 0.5 McFarland turbidity standard — direct colony suspension method |
| Incubation temperature | 35 ± 1°C |
| Incubation duration | 16–20 hours (refer to IFU for organism-specific conditions) |
| MIC reading | µg/mL — read at ellipse/strip intersection point |
| Breakpoint standards | EUCAST Clinical Breakpoint Tables (current edition) / CLSI M100 |
| Pack sizes | 10 and 30 tests — individually packaged strips (agent-dependent) |
| Storage | 2–8°C (refer to product label and IFU) |
| Regulatory category | Class 2 IVD — for in vitro diagnostic use only |
| ARTG number | 524158 |
| Manufacturer | BioMaxima S.A., Lublin, Poland |
| Australian distributor | Advanced Biotech Pty Ltd |
Downloads
Instructions for Use, Safety Data Sheet, and regulatory documentation for RMIC Resistance MIC Test Strips.
Order RMIC or Request Technical Information
Contact Advanced Biotech Pty Ltd for pricing, catalogue numbers, pack sizes, and availability of RMIC Resistance MIC Test Strips in Australia.