The capability to detect ESBLs, AmpC and carbapenemases (KPC and metallo-â-lactamases) in the laboratory is important to improve the clinical management of infections. Disk (tablet) approximation tests detecting synergy (or antagonism) are used to screen and detect the mentioned beta-lactamases. The combination of non-susceptibility to carbapenems with synergism between Phenylboronic Acid and a carbapenem is indicative of KPC beta-lactamase. ROSCO Diagnostica acknowledges the increasing need for detecting mechanisms of resistance and is focusing its research activities in this field. |
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